L-Alanine, N-[(S)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-, 1-methylethyl ester

Name	N-[[S(P)]-[2-(Adenin-9-yl)-1(R)-methylethoxymethyl](phenoxy)phosphoryl]-L-alanine isopropyl ester
Synonyms	GS-7340 GS-7340-03 tenofovir alafenamide GS-7340 Tenofovir alafenamide Tenofovir alafenamide fumarate Tenofovir Alafenamide (GS-7340) N-[[S(P)]-[2-(Adenin-9-yl)-1(R)-methylethoxymethyl](phenoxy)phosphoryl]-L-alanine isopropyl ester (S)-Isopropyl 2-(((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate L-Alanine, N-[(S)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]phenoxyphosphinyl]-, 1-methylethyl ester Tenofovir Alafenamide fumarate, N-[[S(P)]-[2-(Adenin-9-yl)-1(R)-methylethoxymethyl](phenoxy)phosphoryl]-L-alanine isopropyl ester
CAS	379270-37-8
EINECS	1592732-453-0

Molecular Formula	C21H29N6O5P
Molar Mass	476.47
Density	1.39±0.1 g/cm3(Predicted)
Melting Point	>119°C (dec.)
Boling Point	640.4±65.0 °C(Predicted)
Solubility	DMSO: ≥ 31 mg/mL
Appearance	Solid
Color	White to Off-White
pKa	4.21±0.10(Predicted)
Storage Condition	2-8°C(protect from light)
Stability	Hygroscopic
In vitro study	GS-7340 has potent anti-HIV activity with an IC50 of 0.005 μm. The half-lives of GS 7340 at 37 ° C. In human plasma and MT-2 cell extracts were 90 minutes and 28.3 minutes, respectively. Liver uptake of GS 7340 can be promoted by OATP1B1 and OATP1B3, respectively. GS-7340 is converted to a pharmacologically active form-after TFV-DP, HBV reverse transcriptase is inhibited.
In vivo study	In male beagle dogs, GS 7340 (10 mg/kg, p.o.) enhanced distribution to lymphoid tissues.

Last Update：2024-01-02 23:10:35

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